https://hdl.handle.net/20.500.12879/5 PubMed Indexed Publications Collection Sun, 30 Aug 2026 12:35:07 GMT 2026-08-30T12:35:07Z https://hdl.handle.net/20.500.12879/108 White-matter changes in early and late stages of mild cognitive impairment Femir-Gurtuna, Banu; Kurt, Elif; Ulasoglu-Yildiz, Cigdem; Bayram, Ali; Yildirim, Elif; Soncu-Buyukiscan, Ezgi; Bilgic, Basar Mild Cognitive Impairment (MCI) is characterized by cognitive deficits that exceed age-related decline, but not interfering with daily living activities. Amnestic type of the disorder (aMCI) is known to have a high risk to progress to Alzheimer's Disease (AD), the most common type of dementia. Identification of very early structural changes in the brain related to the cognitive decline in MCI patients would further contribute to the understanding of the dementias. In the current study, we target to investigate whether the white-matter changes are related to structural changes, as well as the cognitive performance of MCI patients. Forty-nine MCI patients were classified as Early MCI (E-MCI, n = 24) and Late MCI (L-MCI, n = 25) due to their performance on The Free and Cued Selective Reminding Test (FCSRT). Age-Related White-Matter Changes (ARWMC) scale was used to evaluate the white-matter changes in the brain. Volumes of specific brain regions were calculated with the FreeSurfer program. Both group and correlation analyses were conducted to show if there was any association between white-matter hyperintensities (WMHs) and structural changes and cognitive performance. Our results indicate that, L-MCI patients had significantly more WMHs not in all but only in the frontal regions compared to E-MCI patients. Besides, ARWMC scores were not correlated with total hippocampal and white-matter volumes. It can be concluded that WMHs play an important role in MCI and cognitive functions are affected by white-matter changes of MCI patients, especially in the frontal regions. (C) 2020 Elsevier Ltd. All rights reserved. KURT, ELIF/0000-0003-1956-575X; Femir, Banu/0000-0003-3649-6063; Bilgic, Basar/0000-0001-6032-0856; Bayram, Ali/0000-0002-6588-3479; Yildirim, Elif/0000-0003-3445-9197; Ulasoglu-Yildiz, Cigdem/0000-0003-1849-0055; Soncu Buyukiscan, Ezgi/0000-0003-1305-0560; WOS:000556833000029; PubMed: 32334962 Wed, 01 Jan 2020 00:00:00 GMT https://hdl.handle.net/20.500.12879/108 2020-01-01T00:00:00Z https://hdl.handle.net/20.500.12879/107 Alterations in niban gene expression as a response to stress conditions in 3T3-L1 adipocytes Cevik, Mehtap; Gunduz, Meliha Koldemir; Deliorman, Gokce; Susleyici, Belgin Adipocyte death is important in obesity development. Understanding and prevention of adipocyte deaths may be a molecular approach in the treatment. In the study, we aimed to understand role of Niban gene, which acts as an anti-apoptotic molecule as a response to stress conditions, in adipocytes. 3T3-L1 adipocytes were treated with different doses of linoleic acid, hydrogen peroxide and ethanol; and proliferation of the cells examined with real time monitoring iCELLingence system. Gene expression levels were measured by q-PCR. As a response to 24h 480 mu M linoleic acid treatment, Niban gene expression was found to be higher than control group (p = 0.008), whereas 24 h 90 mM ethanol treatment was determined to be lower than control group (p = 0.008). The highest value of Niban gene expression among H2O2 treatment groups was detected in 4h 600 mu M H2O2 in comparison to control group (p = 0.008). To understand role of Niban in adipogenesis, Niban gene expressions were compared between pre-adipocytes and advanced fat accumulated adipocytes and determined to be significantly different (p = 0.042). Our results suggest that Niban might be involved in stress response process in adipocytes. However, the exact molecular role of Niban needs to be investigated in further studies. WOS:000589439000001; PubMed: 33185830 Wed, 01 Jan 2020 00:00:00 GMT https://hdl.handle.net/20.500.12879/107 2020-01-01T00:00:00Z https://hdl.handle.net/20.500.12879/39 Where can urodynamic testing help assess male lower urinary tract symptoms? Gürbüz, Cenk; Drake, Marcus J. Urodynamic studies assess the function of the bladder and bladder outlet. They are often useful in the assessment and diagnosis of patients presenting with lower urinary tract symptoms (LUTS). The evidence regarding the value and risks of invasive urodynamics remains insufficient. However, men with LUTS who are assessed by invasive urodynamics are more likely to have their management changed and less likely to undergo surgery. This review discusses the role of urodynamic diagnosis and application in the diagnosis and treatment of male LUTS. Tue, 01 Jan 2019 00:00:00 GMT https://hdl.handle.net/20.500.12879/39 2019-01-01T00:00:00Z